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white-matter disease

demyelinating ("myelinoclastic")

  • destruction of existing myelin
  • acquired diseases with inflammatory characteristics
  • includes: MS, PML, encephalomyelitis
  • also may be d/t anoxia, infarct, tumor, radiation

dysmyelinating

  • abnormal myelin formation or maintenance
  • two groups:
    • primary white-matter diseases: leukodystrophies
    • involve gray matter: Niemann-Pick, Gaucher, Tay-Sachs

Charles E. Kahn, Jr., MD  -  2 February 1995
Last updated:  1 October 2013


 

Related CHORUS documents:
demyelinating disease
dysmyelinating disease
acute disseminated encephalomyelitis
disseminated necrotizing leukoencephalopathy
Binswanger disease
Schilder syndrome

 

Copyright © 2013, Charles E. Kahn, Jr.