Laron syndrome

Laron syndrome (LS), also known as growth hormone insensitivity is an autosomal recessive disorder characterized by a lack of insulin-like growth factor 1 (IGF-1)(somatomedin) production in response to growth hormone (GH)(hGH)(somatotropin). It is usually caused by inherited growth hormone receptor (GHR) mutations.Affected individuals classically present with short stature between -4 to -10 standard deviations below median height, obesity, craniofacial abnormalities, micropenis, low blood sugar, and low serum IGF-1 despite elevated basal serum GH.LS is a very rare condition with a total of 250 known individuals worldwide. [Source: Wikipedia ]