Dysgammaglobulinemia is a type of immune disorder characterized by a reduction in some types of gamma globulins, resulting in heightened susceptibility to some infectious diseases where primary immunity is antibody based.It is distinguished from hypogammaglobulinemia, which is a reduction in all types of gamma globulins.Hyper IgM syndrome can be considered a form of dysgammaglobulinemia, because it results from a failure of transformation from IgM production to production of other antibodies, and so the condition can be interpreted as a reduction of the other types. See also Immunodeficiency References Further reading Raif S. Geha et al.: "Hyper Immunoglobulin M Immunodeficiency (Dysgammaglobulinemia)", Journal of Clinical Investigation, 1979 August; 64(2): 385–391, doi:10.1172/JCI109473. [Source: Wikipedia ]