XXXYY syndrome

Down syndrome or Down's syndrome, also known as trisomy 21, is a genetic disorder caused by the presence of all or part of a third copy of chromosome 21. It is usually associated with physical growth delays, mild to moderate intellectual disability, and characteristic facial features. [Source: Wikipedia ]

49,XXXYY syndrome
OrphaNet reference
49,XXXYY syndrome 
May Cause
Congenital heart disease