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mastocytosis


  • proliferation of mast cells
  • seen in hematopoietic regions of skeleton

  • sclerotic bone lesions
    • diffuse osteosclerosis
    • discrete, irregular, sclerotic nodules
    • rarely lytic lesions with densely sclerotic margins

  • mast cells elaborate histamine ==> flushing, tachycardia, nausea, diarrhea
  • pigmented, pruritic rash (urticaria pigmentosa)
  • hepatosplenomegaly, adenopathy
  • thrombocytopenia; increased or decreased WBCs


Charles E. Kahn, Jr., MD  -  2 February 1995
Last updated:  1 October 2013


 

Related CHORUS documents:
diffuse osteosclerosis (dense bone)
tubular (toothpaste) small bowel
graft-vs.-host disease
osteopetrosis (Albers-Schoenberg disease)
pyknodysostosis
aneurysmal bone cyst

 

Copyright © 2013, Charles E. Kahn, Jr.