fibrous dysplasia

xray: "ground glass" lesion with sclerotic rim
may be expansile, predominantly metaphysis to diaphysis
labs: increased alk phos, o/w normal
monostotic form
- any bone (ribs, femur, tibia most common)
- diametaphyseal
polyostotic form
- unilateral predominance
- not familial (except cherubism)
- scalloping, expansion, deformity (Sheperd's crook)
other forms
- McCune-Albright syndrome (with precocious puberty)
- leontiasis ossea (involves skull and facial bones)
- cherubism (hereditary form, involves mandible)

Charles E. Kahn, Jr., MD - 2 February 1995
Last updated: 1 October 2013