cleidocranial dysostosis

disorder of ossification/development of midline bones

autosomal dominant, 33% sporadic

skull
- cranial dysplasia
- Wormian bones
- basilar invagination
clavicles
- aplasia / hypoplasia, usually lateral portion
other skeletal abnormalities
- small, high scapula
- wide symphysis pubis
- acro-osteolysis

Charles E. Kahn, Jr., MD - 2 February 1995
Last updated: 1 October 2013