Castleman disease

angiofollicular lymph node hyperplasia
benign lymphoid hyperplasia
massively enlarged lymph nodes
mediastinum most common; rarely in mesentery
age < 30 yrs
types: hyaline vascular (90%)
- asymptomatic
- vascular proliferation + hyalinization
plasma cell (10%)
- fever
- anemia
- increased sed rate, increased IgG

Charles E. Kahn, Jr., MD - 2 February 1995
Last updated: 1 October 2013