CHORUS
Collaborative Hypertext of Radiology
Musculoskeletal system
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inclusion body myositis
common form of inflamatory myopathy
- most common in the elderly
- equal sex incidence
- sporadic idiopathic disease (very rarely familial)
- misdiagnosed as steroid-resistant polymyositis
symptoms
- presents as a painless slowly progressive proximal myopathy
- may cause dysphagia
- mild to moderate muscle wasting
diagnosis
- serum creatine kinase levels usually normal or only slightly elevated
- EMG may show non-specific myopathic features
- diagnosis on muscle biopsy
- inclusion bodies seen in rimmed vacuoles in skeletal muscle fibres
treatment
- steroids and immunosuppression generally ineffective
- rare patients reported who have made a response to treatment
pathogenesis
- unknown
- ubiquitin, prion protein, tau protein found in inclusions
- abnormal mitchondria seen in some case
James Lowe, DM BM BS MRCPath - 13 November 1997
Last updated: 1 October 2013
Copyright © 2013, Charles E. Kahn, Jr.
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