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Collaborative Hypertext of Radiology

Musculoskeletal system



hypervitaminosis A

  • acute
    • ingestion of >1,000,000 IU --> increased intracranial pressure

  • chronic
    • 1-3 years
    • pruritis
    • hard, tender masses in extremities
    • long latency between intake and sxs

xray findings:

  • periostitis in diaphyses of ulnae and metatarsals
  • symmetric
  • can cause premature fusion of ossification centers

DDx: Caffey disease

  • younger patients
  • no elevation of vitamin A levels
  • different distribution of lesions (i.e. mandible often affected)

Brian Funaki, MD  -  8 February 1995
Last updated:  1 October 2013


Related CHORUS documents:
Caffey disease
diffuse osteosclerosis (dense bone)
Hurler's syndrome
McCune-Albright syndrome
periosteal reaction
von Hippel-Lindau syndrome


Copyright © 2013, Charles E. Kahn, Jr.