CHORUS

Collaborative Hypertext of Radiology

Musculoskeletal system

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hypervitaminosis A

• acute
  • ingestion of >1,000,000 IU --> increased intracranial pressure

• chronic
  • 1-3 years
  • pruritis
  • hard, tender masses in extremities
  • long latency between intake and sxs

xray findings:

• periostitis in diaphyses of ulnae and metatarsals
• symmetric
• can cause premature fusion of ossification centers

DDx: Caffey disease

• younger patients
• no elevation of vitamin A levels
• different distribution of lesions (i.e. mandible often affected)

Related CHORUS documents: Caffey disease diffuse osteosclerosis (dense bone) Hurler's syndrome McCune-Albright syndrome periosteal reaction von Hippel-Lindau syndrome

Copyright © 2013, Charles E. Kahn, Jr.