CHORUS

Collaborative Hypertext of Radiology

Musculoskeletal system

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sickle cell anemia: bone manifestations

• 8-13% of blacks carry sickling factor
• symptoms: chronic ulcers, pain crises, many infections, priapism

• deossification due to marrow hyperplasia
  • decreased bone density in skull with widened diploic space
  • "H-shaped vertebrae" or "fish vertebrae"
  • rib notching
• thrombosis and infarction
  • AVN, esp. femoral head
  • periosteal rxn ("bone within bone")
• secondary osteomyelitis
  • Staph. aureus > Salmonella
  • dactylitis = hand foot syndrome
• growth effects
  • bone shortening secondary to diminished blood supply

• death < 40y

Related CHORUS documents: avascular necrosis (AVN) bone within a bone gallstones progeria (Hutchinson-Gilford) syndrome avascular necrosis (AVN) staging pancreatitis

Copyright © 2013, Charles E. Kahn, Jr.