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Musculoskeletal system

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multiple myeloma

  • most common primary malignant neoplasm of bone
  • 50-70y; M:F 2:1

  • symptoms: vague bone pain of progressive severity, fever, anemic sxs
  • complications: pathologic fractures

  • solitary plasmacytoma: solitary osseous focus of MM (uncommon)

x-ray findings:
  • loss of bone density - from diffuse marrow involvement
  • "punched out" lesions - esp. skull, long bones
  • diffuse bone destruction - esp. pelvis, sacrum
  • invasion of soft tissues - often paraspinal, extrapleural mass
  • osteosclerosis - very rare
  • metastatic calcifications - particularly kidneys, occ. lungs
NB: does not involve pedicles of spine

Brian Funaki, MD  -  6 February 1995
Last updated:  1 October 2013


 

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Copyright © 2013, Charles E. Kahn, Jr.