acute lymphocytic leukemia (ALL)

95% of cases of leukemia in children
bone changes in 50-70% of kids (vs. 10% in adults); seen as early as 1 month after onset of symptoms
wrists and knees most commonly affected
bony defects:
1. metaphyseal radiolucent bands!
  (similar findings in scurvy, JRA, syphilis)
2. osteolytic lesions
3. periosteal reaction
4. osteosclerosis

Brian Funaki, MD - 6 February 1995
Last updated: 1 October 2013