CHORUS
Collaborative Hypertext of Radiology
Multisystem entities
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Wegener granulomatosis
- sinuses and upper respiratory tract (100%)
- mucoperiosteal thickening
- rhinorrhea and epistaxis
- may destroy bone + cartilage
- lungs
- necrotizing granulomata
- multiple round nodules (2 mm - 9 cm)
- alveolar infiltrates
- may cavitate
- kidneys (83%)
- glomerulonephritis ==> necrosis of capillary tuft
- generalized necrotizing vasculitis of arteries + veins
- auto-immune: basement membrane
- almost always involves lungs
- M = F, 30-50 y/o
- sx: cough, hemoptysis, fever, wt loss, multiple resp. infections
- tx: cyclophosphamide, corticosteroids (90% complete remission)
- 90% mortality within 2 years if untreated (renal>pulmonary failure)
Charles E. Kahn, Jr., MD - 27 January 1996
Last updated: 1 October 2013
Copyright © 2013, Charles E. Kahn, Jr.
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