CHORUS - home page

CHORUS

Collaborative Hypertext of Radiology


Multisystem entities

About CHORUS
Disclaimer
Copyright

 

Wegener granulomatosis


  • sinuses and upper respiratory tract (100%)
    • mucoperiosteal thickening
    • rhinorrhea and epistaxis
    • may destroy bone + cartilage

  • lungs
    • necrotizing granulomata
    • multiple round nodules (2 mm - 9 cm)
    • alveolar infiltrates
    • may cavitate

  • kidneys (83%)
    • glomerulonephritis ==> necrosis of capillary tuft

  • generalized necrotizing vasculitis of arteries + veins
    • auto-immune: basement membrane
    • almost always involves lungs

  • M = F, 30-50 y/o
  • sx: cough, hemoptysis, fever, wt loss, multiple resp. infections
  • tx: cyclophosphamide, corticosteroids (90% complete remission)
  • 90% mortality within 2 years if untreated (renal>pulmonary failure)


Charles E. Kahn, Jr., MD  -  27 January 1996
Last updated:  1 October 2013


 

Related CHORUS documents:
cavitary lung nodules
rheumatoid lung disease
absent nasal septum
eosinophilic granuloma
gallbladder carcinoma
Sjogren syndrome

 

Copyright © 2013, Charles E. Kahn, Jr.